Table 2 Neurotransmitter systems and suicide
From: The neurobiology of suicide - A Review of post-mortem studies
| System element | Change | Location | ||
|---|---|---|---|---|
| SEROTONERGIC | Receptors | 5HT-1A | upregulated | RN, FC |
| 5HT-1D | downregulated | PFC | ||
| 5HT-2A | downregulated | PFC, HIP, FPC | ||
| 5HT-2C | upregulated | PFC | ||
| 5-HT4 | upregulated | FC, HIP, CN, AN | ||
| Enzymes | TPH | upregulated | RN | |
| Transporter | Serotonin transporter | downregulated | PFC, RN | |
| NORADRENERGIC | Receptors | Alpha-1 | downregulated | PFC, TC, CN |
| Alpha-2 | upregulated in drug-free subjects | HIP, FC, LC, HTH | ||
| downregulated in antidepressant- treated subjects | OC, HIP | |||
| Alpha-2A | upregulated in drug-free subjects | EC, HTH, PEE | ||
| downregulated in antidepressanttreated subjects | AN, CN | |||
| Beta | upregulated | PFC, TC | ||
| Alpha-2 ‘Beta ratio | increased | G | ||
| Enzymes | TH | upregulated | LC | |
| DOPAMINERGIC | Dopamine turnover | Dihydroxy- phenylacetic acid concentration | decreased | CN, P. NA |
| GLUTAMATERGIC | Receptors | NMDA | downregulated | G |
| Zinc inhibition decreased | HIP | |||
| AMPA | upregulated | CN | ||
| GABA-ERGIC | Receptors | GABA | upregulated | FC |
| ENDOCANNABINOID | Receptors | CB(1) | upregulated | PFC |