The neurobiology of suicide - A Review of post-mortem studies

Table 3 Cell-signalling in suicide

System element			Change	Location
Adenylate cyclase	Protein kinase A	Enzyme activity	decreased	PFC, HIP
		Enzyme subunits RIl, C3 levels	decreased	PFC, adult suicides
		Enzyme subunits Rkt, R113 levels	decreased	PFC, teenage suicides
		Enzyme substrate Rap- 1	reduced activation	PFC, HIP
	Second messenger	cAMP level	increased	PC, CN
	cAMP effector	Epac-2 level	increased	PFC, HIP
		CREB level	decreased	PFC, HIP
			increased	PFC, antidepressants-free subjects
			increased density of CREB stained cells	AN
Phospholipase C	Protein kinase C	Enzyme activity	decreased	PFC, HIP, teenage suicides
	Protein kinase C	Enzyme substrate MARCKS	increased concentration, decreased phosphorylation	PFC, HIP
	Second messenger	IP3 level	increased	HIP, CN
Cytokines	Interleukins	IL-1β level	increased	FC, teenage suicide
		IL-3 level	increased	PC, female suicides
		IL-4 level	increased	FC, female suicides
		IL-6 level	increased	PC, teenage suicide
		IL-13 level	increased	PC, male suicides
	TNF-Family	TNF-α level	increased	PC, teenage suicide

ISSN: 2049-9256