Insights into the origin of DNA methylation differences between monozygotic twins discordant for schizophrenia

Table 1 Most significant pathways and networks identified by IPA of genes showing significant (p < 0.001) promoter hypermethylation (A) and hypomethylation (B) of the schizophrenia affected vs. healthy monozygotic twins in twin pair 1

A)
Canonical Pathways	P-value	Ratio^a
HIPPO signaling	3.93E-03	4/85 (0.047)
MAPK Signaling	4.27E-03	4/87 (0.046)
Molecular and Cellular Functions
Cell Cycle, DNA Replication, Recombination	1.69E-04–1.51E-02	6
Cellular development, growth and proliferation	1.16E-03–4.45E-02	24
Cell Death and Survival	1.67E-03–4.54E-02	22
Diseases and Disorders
Developmental disorder	3.56E-03–4.72E-02	16
Hereditary disorder	3.56E-03–2.99E-02	22
Organismal injury and abnormalities	3.56E-03–4.91E-02	45
Most Significant Networks		#of molecules
Cellular Growth, Proliferation, Cellular movement & development		131
Cell Death and Survival, Cellular movement		69
B)
Canonical Pathways	P-value	Ratio^a
Dopamine-DARPP32 feedback in cAMP signaling	7.43E-03	6/157 (0.038)
Calcium Signalling	1.08E-02	6/170 (0.035)
Ephrin Receptor Signalling	1.13E-02	6/172 (0.035)
Molecular and Cellular Functions
Gene expression	3.75E-04–4.97E-02	37
Cellular Assembly and Organization	1.15E-03–4.61E-02	22
Small Molecule Biochemistry	3.39E-03–4.51E-02	16
Lipid Metabolism	3.39E-03–3.69E-02	6
Diseases and disorders		# of molecules
Metabolic disease	3.38E-04–4.28E-02	17
Endocrine system disorders	1.95E-04–4.42E-02	21
Nervous system development and function	1.71E-03–4.28E-02	3
Most Significant Networks
Cell-mediated Immune Response, Cellular Movement		60
Cell Cycle, Cellular Development		56

^aThe number of molecules that reach the threshold of significant methylation difference between twins
(Peak score > =3.1)

ISSN: 2049-9256